Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

52.7K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
52.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption.

Cancer cell·2026
Same author

An extracellular, optogenetic antibody platform for stimulus-gated antigen recognition and modulation of cell behavior.

Cell chemical biology·2026
Same author

Signaling Connectomics: A Brain-wide Framework for Intercellular Communication.

Experimental neurobiology·2026
Same author

Integrative Multiomic Classification Reveals Distinct Origins and Evolutionary Trajectories of Thymic Epithelial Tumors.

Cancer research·2026
Same author

AI-driven decoding of naturalistic behaviors enables tailored detection of depressive-like behavior in mice.

Nature communications·2025
Same author

Optogenetic engineering of BAX to control mitochondrial permeabilization and attenuate apoptosis in cells.

Experimental & molecular medicine·2025

Related Experiment Video

Updated: Dec 30, 2025

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

9.1K

Optogenetic tools for dissecting complex intracellular signaling pathways.

Eury Kwon1, Won Do Heo2

  • 1Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.

Biochemical and Biophysical Research Communications
|January 18, 2020
PubMed
Summary
This summary is machine-generated.

Optogenetic technologies use light to control intracellular signaling networks by modulating protein interactions in space and time. This review explores optical tools for manipulating cell signaling and their future potential.

Keywords:
Intracellular signaling pathwaysOptogenetic toolsOptogeneticsPhotoreceptors

More Related Videos

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.7K
Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits
09:17

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits

Published on: March 14, 2018

10.5K

Related Experiment Videos

Last Updated: Dec 30, 2025

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

9.1K
Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.7K
Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits
09:17

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits

Published on: March 14, 2018

10.5K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biotechnology

Background:

  • Intracellular signaling involves complex, dynamic protein-protein interactions.
  • Dissecting these networks is crucial for understanding cellular functions.
  • Optogenetics offers precise spatial and temporal control over cellular processes.

Purpose of the Study:

  • To review optical strategies for manipulating intracellular signaling proteins and secondary messengers.
  • To explore engineering optogenetic actuators for protein interactions.
  • To discuss the application and future of optogenetics in cell signaling.

Main Methods:

  • Overview of light-inducible optogenetic technologies.
  • Discussion of genetic and optical methods for controlling protein function.
  • Survey of optical tools and targeting strategies for signaling pathways.

Main Results:

  • Optogenetics enables precise modulation of intracellular signaling at the molecular level.
  • Engineering actuators can enhance homo- or hetero-protein interactions.
  • Optogenetic approaches are extendable to in vivo systems.

Conclusions:

  • Optogenetic tools provide powerful means to dissect and control complex intracellular signaling networks.
  • Future prospects include advanced in vivo applications and novel actuator designs.
  • This technology holds significant potential for fundamental research and therapeutic development.