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Advanced imaging for risk stratification of sudden death in hypertrophic cardiomyopathy

Jay Ramchand1, Agostina M Fava1, Michael Chetrit1

  • 1Heart and Vascular Institute, Cleveland Clinic Miller Family Heart and Vascular Institute, Cleveland, Ohio, USA.

Heart (British Cardiac Society)
|January 18, 2020
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) patients at high risk of sudden cardiac death (SCD) can benefit from implantable cardiac defibrillators (ICDs). Cardiac imaging advances help identify these patients, guiding ICD implantation and reducing risks.

Area of Science:

  • Cardiology
  • Genetics
  • Medical Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) is a prevalent inherited cardiac disease characterized by left ventricular hypertrophy.
  • A subset of HCM patients face an elevated risk of sudden cardiac death (SCD) due to ventricular arrhythmias.
  • Implantable cardiac defibrillators (ICDs) effectively mitigate SCD risk but carry potential complications like inappropriate shocks.

Purpose of the Study:

  • To review the diagnostic role of cardiac imaging in HCM.
  • To explore how specific imaging features aid in stratifying SCD risk in HCM patients.
  • To guide the selection of appropriate candidates for ICD implantation.

Main Methods:

  • Review of current literature on cardiac imaging in HCM.
  • Analysis of imaging features associated with SCD risk.
  • Evaluation of imaging's role in ICD implantation decisions.

Main Results:

  • Cardiac imaging is crucial for diagnosing HCM.
  • Specific imaging biomarkers correlate with increased SCD risk in HCM.
  • Imaging facilitates personalized risk assessment for ICD therapy.

Conclusions:

  • Advances in cardiac imaging are pivotal for risk stratification in HCM.
  • Imaging-guided approaches can optimize ICD implantation for SCD prevention.
  • Personalized risk assessment using cardiac imaging is essential for managing HCM patients at risk of SCD.

Keywords:
cardiac arrestcardiac magnetic resonance (CMR) imagingechocardiographyhypertrophic cardiomyopathyimplanted cardiac defibrillators

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