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Edible unclonable functions.

Jung Woo Leem1, Min Seok Kim2, Seung Ho Choi3

  • 1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, 47907, USA.

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Counterfeit medicines pose a global threat. This study introduces edible, on-dose physically unclonable functions (PUFs) using biomaterials for robust pharmaceutical anti-counterfeiting and secure authentication.

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Area of Science:

  • Materials Science
  • Pharmaceutical Science
  • Biotechnology

Background:

  • Counterfeit medicines present a significant global security challenge, threatening patient safety and economic stability.
  • Existing anti-counterfeiting solutions often lack sufficient security, leaving them vulnerable to replication.
  • The need for advanced, integrated security measures in pharmaceuticals is critical.

Purpose of the Study:

  • To develop and demonstrate edible, on-dose physically unclonable functions (PUFs) for pharmaceutical anti-counterfeiting.
  • To create a secure authentication system that can be directly applied to individual medication doses.
  • To explore the use of biomaterials for creating unique, verifiable digital fingerprints on pharmaceuticals.

Main Methods:

  • Fabrication of on-dose PUFs using edible photonic biomaterials, specifically fluorescent and silk proteins.
  • Integration of these PUFs directly onto the surface of medicines for swallowable application.
  • Utilizing photoluminescent properties to generate challenge-response pairs for authentication.
  • Testing the PUFs for their ability to be digested and their cryptographic primitive functions.

Main Results:

  • Successful development of edible PUFs that can be attached to medicines and are ingestible.
  • Demonstration of photoluminescent properties supporting unique challenge-response pairs for authentication.
  • The edible cryptographic primitives offer immediate destruction or vanishing features post-authentication.
  • The proposed system provides a high level of security against counterfeit medications.

Conclusions:

  • Edible on-dose PUFs represent a novel and highly secure approach to combating counterfeit medicines.
  • The use of fluorescent and silk proteins as edible photonic biomaterials is effective for pharmaceutical authentication.
  • This technology offers a promising solution for pharmaceutical anti-counterfeiting and other security applications requiring vanishing features.