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Updated: Dec 30, 2025

Peptide-based Identification of Functional Motifs and their Binding Partners
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Targeting Forward and Reverse EphB4/EFNB2 Signaling by a Peptide with Dual Functions

Chiyi Xiong1, Yunfei Wen2, Jun Zhao1

  • 1Departments of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77054, United States.

Scientific Reports
|January 18, 2020
PubMed
Summary

Researchers developed BIDEN-AP, a novel peptide targeting EphB4, to treat ovarian cancer. This dual-function therapeutic suppresses tumor cell invasion and angiogenesis, showing significant potential in preclinical studies.

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