lncRNA-Triggered Macrophage Inflammaging Deteriorates Age-Related Diseases

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Lulingxiao Nie1,2, Peng Zhang1,2, Qian Wang1,2

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, China.

Mediators of Inflammation
|January 18, 2020
PubMed

Insights

Inflammaging, a chronic inflammation in aging, drives age-related diseases by impairing macrophage function. Long non-coding RNAs (lncRNAs) regulate this process, offering potential therapeutic targets for these conditions.

Area of Science:

  • Gerontology
  • Immunology
  • Molecular Biology

Background:

  • Aging is characterized by chronic, low-grade inflammation known as inflammaging.
  • Inflammaging is linked to age-related diseases (ARDs) and involves cellular senescence, oxidative stress, and DNA damage.
  • Long non-coding RNAs (lncRNAs) play a regulatory role in these aging processes.

Purpose of the Study:

  • To review the involvement of macrophage inflammaging in ARDs.
  • To explore the regulatory mechanisms of lncRNAs in inflammaging and ARDs.
  • To highlight lncRNAs as potential therapeutic targets for ARDs.

Main Methods:

  • Literature review focusing on inflammaging, macrophages, and lncRNA.
  • Analysis of molecular pathways linking cellular senescence, SASP, and inflammasomes.
  • Examination of lncRNA interactions with genes and proteins in ARDs.

Main Results:

  • Macrophage inflammaging impairs immunosurveillance and phagocytosis, hindering the clearance of senescent and malignant cells.
  • Senescence-associated secretory phenotypes (SASPs) from macrophages induce paracrine senescence, escalating organ dysfunction.
  • lncRNAs modulate inflammaging and ARDs by targeting genes/proteins or acting as competing endogenous RNAs (ceRNAs).

Conclusions:

  • Macrophage inflammaging is a key driver of ARDs, exacerbated by lncRNA dysregulation.
  • Understanding lncRNA mechanisms in inflammaging is crucial for developing novel ARD treatments.
  • Targeting lncRNAs presents a promising strategy for mitigating ARDs and promoting healthy aging.

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