Bioinformatics Analysis of Potential Key Genes in Trastuzumab-Resistant Gastric Cancer
Guangda Yang1, Liumeng Jian2, Xiangan Lin3
1Department of Cancer Chemotherapy, Zengcheng District People's Hospital of Guangzhou (BoJi-Affiliated Hospital of Sun Yat-sen University), Guangzhou, China.
Disease Markers
|January 18, 2020
Summary
This study identified four key genes (ERBB2, VIM, EGR1, PSMB8) associated with trastuzumab resistance in gastric cancer. Interferon-stimulated genes (ISGs) may also play a significant role in developing this resistance.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Acquired trastuzumab resistance is a significant challenge in treating HER2-positive gastric cancer (GC).
- Identifying novel therapeutic targets is crucial for overcoming treatment resistance.
Purpose of the Study:
- To identify genes associated with acquired trastuzumab resistance in gastric cancer.
- To investigate the prognostic value of these identified genes.
Main Methods:
- Utilized gene expression data (GSE77346) from the Gene Expression Omnibus (GEO) database.
- Identified differentially expressed genes (DEGs) and constructed a protein-protein interaction (PPI) network to pinpoint hub genes.
- Analyzed the prognostic significance of hub genes using the Kaplan-Meier plotter tool.
Main Results:
- Screened 327 DEGs, with enrichment in cancer pathways, stem cell pluripotency, and ECM-receptor interactions.
- Identified 18 hub genes from the PPI network, including upregulated and downregulated genes.
- Found four hub genes (ERBB2, VIM, EGR1, PSMB8) significantly related to the prognosis of HER2-positive gastric cancer; most other hub genes were interferon-stimulated genes (ISGs).
Conclusions:
- The four identified hub genes are potential therapeutic targets for trastuzumab-resistant gastric cancer.
- Interferon-stimulated genes (ISGs) are implicated in promoting trastuzumab resistance in gastric cancer.
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