Growth hormone-secreting adenoma coexisted with gangliocytoma: a rare case

A gangliocytoma in the sellar region is extremely rare. We report a rare case of mixed gangliocytoma and growth hormone (GH)-secreting adenoma in a 50-year-old woman, who presented with acromegaly. Laboratory investigations revealed high levels of GH and insulinlike growth factor 1 (IGF-1). Sellar computed tomography scan and contrast enhanced magnetic resonance imaging (CE-MRI) showed a sellar mass. Based on clinical, biochemical, and radiologic evaluations, GH-secreting adenoma was diagnosed and operated by endonasal transsphenoidal approach achieving total removal of the tumor. After surgery, histopathological examination demonstrated mixed gangliocytoma and GH-secreting adenoma in the resected lesion. The clinical, radiological, and operative data are reviewed, as are the histological findings. To our knowledge, few cases of mixed gangliocytoma and GH-secreting adenoma have been reported.