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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Updated: Dec 30, 2025

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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Primary pulmonary synovial sarcoma: a case report.

Junfeng Liu1, Zhaoming Nie1, Jianyao Lv2

  • 1Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University Guangzhou, People's Republic of China.

International Journal of Clinical and Experimental Pathology
|January 18, 2020
PubMed
Summary
This summary is machine-generated.

Primary pulmonary synovial sarcoma (PPSS) is a rare, aggressive lung tumor. Endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) with in situ hybridization aids in its diagnosis.

Keywords:
EWSR1 genePrimary pulmonary synovial sarcomaSYT genediagnosis

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Area of Science:

  • Oncology
  • Pulmonology
  • Pathology

Background:

  • Primary pulmonary synovial sarcoma (PPSS) is a rare mesenchymal tumor, comprising 0.5% of primary lung malignancies.
  • PPSS is known for its aggressive nature and high potential for progression.

Observation:

  • A 52-year-old male presented with a large, heterogeneous mass (8.5 × 7.7 × 6.5 cm) on chest CT, with bilateral pulmonary nodules.
  • Initial investigations included CT imaging, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), and histopathological examination (H&E, immunohistochemistry), raising suspicion for sarcoma.

Findings:

  • Molecular analysis, specifically in situ hybridization, confirmed PPSS by detecting SYT gene expression (positive) and EWSR1 gene expression (negative).
  • This molecular detection was crucial in differentiating PPSS from other potential diagnoses.

Implications:

  • This case highlights the diagnostic utility of EBUS-TBNA combined with in situ hybridization for diagnosing rare pulmonary sarcomas.
  • The findings suggest that this integrated diagnostic approach can improve the accuracy and timeliness of PPSS diagnosis.
  • Early and accurate diagnosis is critical for effective management of this aggressive malignancy.