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An Unusual Initial Presentation of Diffuse Large B-Cell Lymphoma as Recurrent Syncope
Kunhwa Kim1, Harpreet Kaur1, Matthew Chan1
1Department of Internal Medicine, Einstein Medical Center Philadelphia, Philadelphia, PA, USA.
Case Reports in Hematology
|January 18, 2020
Summary
A rare case of diffuse large B-cell lymphoma (DLBCL) presented as recurrent syncope. Successful DLBCL treatment resolved the syncope episodes, highlighting an unusual lymphoma manifestation.
Area of Science:
- Oncology
- Hematology
- Cardiology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
- Lymphoma typically presents with B symptoms or lymphadenopathy.
- Syncope is usually associated with cardiac or neurological conditions.
Observation:
- A patient presented with recurrent episodes of syncope.
- Incidental discovery of an extensive left thoracic mass during syncope workup.
- The mass was diagnosed as stage 2 bulky diffuse large B-cell lymphoma.
Findings:
- This case represents a rare presentation of DLBCL.
- The lymphoma manifested as recurrent syncope without cardiac involvement.
- Syncope resolved completely following successful DLBCL treatment.
Implications:
- Highlights the importance of thorough investigation for unusual presenting symptoms of lymphoma.
- Suggests a potential paraneoplastic or mass effect mechanism for syncope in DLBCL.
- Underscores the diagnostic challenge and diverse clinical manifestations of DLBCL.
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