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Updated: Dec 30, 2025

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
A case of severe hepatotoxicity induced by cisplatin and 5-fluorouracil
Ayaka Yaegashi1, Kensuke Yoshida1, Naoto Suzuki1
11Department of Pharmacy, Niigata University Medical and Dental Hospital, 754-banchi, Asahimati-dori 1-bancho, Chuo-ku, Niigata, 951-8520 Japan.
Abstract:
Severe hepatotoxicity from combination chemotherapy with cisplatin and 5-fluorouracil is a rare adverse effect. In this case report, we present a case with severe hepatotoxicity immediately following chemotherapy with cisplatin and 5-fluorouracil. This female patient had previously been treated with this combination with no hepatotoxicity. The elevated liver enzymes quickly normalized after chemotherapy was stopped. There were no specific changes in liver imaging. As hepatotoxicity occurred after repeated administration of cisplatin, we suggest that this hepatotoxicity might represent a case of allergic hepatitis caused by cisplatin. Severe hepatotoxicity should be watched for with repeated administration of cisplatin.
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