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Selective retrograde cerebral cooling in complete cerebral circulatory arrest
Bridget C Vaughan1, Melissa E R Jones1,2, Ikennah L Browne1,3
1Voyage Biomedical Inc., Berkeley, CA, United States.
Brain Circulation
|January 18, 2020
Summary
Selective cerebral cooling offers neuroprotection for acute ischemic stroke (AIS) without systemic side effects. A novel endovascular device demonstrated feasibility in human anatomy for this targeted therapeutic hypothermia approach.
Area of Science:
- Neuroscience
- Cardiovascular Research
- Medical Device Technology
Background:
- Therapeutic hypothermia is a neuroprotectant for ischemic events.
- Systemic cooling is used post-cardiac arrest but has risks.
- Selective cerebral cooling aims to mitigate risks of whole-body cooling for acute ischemic stroke (AIS).
Purpose of the Study:
- To evaluate selective retrograde cerebral cooling efficacy in a porcine model.
- To assess a novel endovascular device for selective cerebral cooling.
- To validate the device in human anatomy.
Main Methods:
- Selective retrograde cerebral cooling via the internal jugular vein was tested in a porcine model during complete cerebral circulatory arrest (n=3).
- A novel endovascular device and cooling system were studied in a normothermic perfused cadaver.
Main Results:
- Neurologic assessments showed significant neuroprotection in animals after 15 and 30 minutes of cerebral circulatory arrest.
- The endovascular device and cooling system were successfully validated in human anatomy.
- The mechanism of selective retrograde cerebral cooling proved feasible.
Conclusions:
- Selective cerebral cooling provides substantial neuroprotection during acute ischemic events.
- The novel endovascular device is effective and feasible for targeted cerebral cooling.
- This approach holds promise for treating acute ischemic stroke.
