Related Experiment Video
Updated: Dec 30, 2025
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Multimodal Therapy for Sinonasal Malignancies: Updates and Review of Current Treatment
Mayur D Mody1,2, Nabil F Saba3,4
1Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
Opinion Statement:
Sinonasal malignancies pose a significant challenge in management due to their low incidence, biologic diversity, and significant symptom burden. Even though surgery remains the primary therapeutic modality, a multi-modality approach has been shown to benefit a significant proportion of patients and its success depends largely on stage and histologic type. Non-surgical approaches such as novel radiation approaches as well as intensification with systemic therapy hold promise in altering the organ preservation rate as well as overall survival for patients. Practice changing randomized trials to test these novel modalities are overdue and desperately needed.
Insights
Sinonasal malignancies present management challenges due to rarity and diversity. Multimodality treatment, including novel radiation and systemic therapies, shows promise for improving organ preservation and survival, necessitating further trials.
Area of Science:
- Oncology
- Otorhinolaryngology
Background:
- Sinonasal malignancies are rare, diverse, and cause significant symptoms.
- Surgery is the primary treatment, but outcomes depend on stage and histology.
- Multimodality approaches can improve outcomes for many patients.
Purpose of the Study:
- To review the current challenges in managing sinonasal malignancies.
- To highlight the potential of non-surgical therapeutic advancements.
- To emphasize the need for practice-changing clinical trials.
Main Methods:
- Literature review of sinonasal malignancy management.
- Analysis of current therapeutic modalities and their outcomes.
- Discussion of emerging non-surgical treatment strategies.
Main Results:
- Surgery remains the cornerstone of treatment for sinonasal cancers.
- Multimodality treatment, tailored to stage and histology, offers significant benefits.
- Novel radiation techniques and systemic therapies show promise for organ preservation and survival.
Conclusions:
- Effective management of sinonasal malignancies requires a comprehensive, individualized approach.
- Advancements in radiation and systemic therapies offer new hope for patients.
- Urgent need for randomized trials to validate novel treatment modalities and improve patient outcomes.
Related Concept Videos
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:56Treatment Resistant Cancers
01:27Tumor Immunotherapy
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...