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Updated: Dec 30, 2025
11:32
A Hydrogen-Deuterium Exchange Mass Spectrometry HDX-MS Platform for Investigating Peptide Biosynthetic Enzymes
Published on: May 4, 2020
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Base metal-catalyzed hydrogen isotope exchange
1Department of Process Research and Development, Merck & Co, Inc, Rahway, New Jersey.
Journal of Labelled Compounds & Radiopharmaceuticals
|January 18, 2020
Summary
Base metal catalysts are emerging for hydrogen isotope exchange (HIE) in pharmaceutical deuteration and tritiation. These new methods offer complementary activity and selectivity for isotopic labeling.
Area of Science:
- Organic Chemistry
- Catalysis
- Medicinal Chemistry
Background:
- Hydrogen isotope exchange (HIE) is crucial for pharmaceutical deuteration and tritiation.
- Previous reviews focused on precious metal catalysts, with limited attention to base metals.
- Base metal catalysts for HIE were historically underdeveloped compared to precious metals.
Purpose of the Study:
- To review recent advancements in base metal catalysts for HIE.
- To highlight their application in isotopic labeling of pharmaceutical compounds.
- To showcase how these methods complement existing techniques.
Main Methods:
- Focus on homogeneous iron, nickel, and cobalt catalysts for HIE.
- Discussion of recent developments and their catalytic systems.
- Analysis of applications in pharmaceutical isotopic labeling.
Main Results:
- Introduction of the first homogeneous iron, nickel, and cobalt catalysts for HIE.
- Development of novel labeling approaches with enhanced activity and selectivity.
- Diversification of methodologies available for isotope chemists.
Conclusions:
- Base metal catalysts represent a significant advancement in HIE chemistry.
- These catalysts offer promising alternatives for isotopic labeling in drug discovery.
- The field is expanding, providing more options for synthetic chemists.
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