ABO blood groups as a new potential predictive factor in radiotherapy hematological changes

Area of Science:

• Oncology
• Hematology
• Radiotherapy

Background:

• Radiotherapy is a cornerstone of cancer treatment, with ongoing advancements in technology and predictive factors.
• Tumor oxygenation and blood flow are critical for radiosensitivity, making blood group antigens a potential predictive factor for treatment response and adverse events.

Purpose of the Study:

• To assess hematological changes during local radiotherapy.
• To investigate the association between these hematological changes and ABO blood groups.

Main Methods:

• An observational study involving 152 patients undergoing 3D conformal radiotherapy.
• Peripheral blood samples were collected at four stages during treatment.
• Blood parameters were analyzed using repeated measures and one-way ANOVA.

Main Results:

• Significant reductions in platelet, white blood cell (WBC), and lymphocyte counts were observed.
• An increased percentage of polymorphonuclear cells was noted during radiotherapy.
• Changes in WBC counts were significantly associated with ABO blood groups.

Conclusions:

• Radiotherapy is associated with significant hematological alterations.
• ABO blood groups are linked to specific hematological changes observed during radiotherapy, suggesting a potential role in predicting patient outcomes.