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Updated: Dec 30, 2025
08:25
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
12.6K
Visualization of circular RNAs and their internal splicing events from transcriptomic data
Yi Zheng1, Fangqing Zhao1,2
1Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.
Bioinformatics (Oxford, England)
|January 18, 2020
Summary
This study introduces CIRI-vis, a new tool for visualizing circular RNA (circRNA) splicing patterns. CIRI-vis helps researchers explore complex circRNA transcriptomes and compare them across samples.
Area of Science:
- Bioinformatics
- Computational Biology
- Genomics
Background:
- Circular RNAs (circRNAs) exhibit unique splicing patterns distinct from messenger RNAs (mRNAs).
- Existing tools lack comprehensive visualization for complex circRNA transcriptomes.
Purpose of the Study:
- To develop CIRI-vis, a novel Java command-line tool for quantifying and visualizing circRNAs.
- To enable exploration of internal circRNA structures and isoform abundance.
Main Methods:
- Integration of alignment and junction data for circular transcripts.
- Development of a Java-based command-line application.
Main Results:
- CIRI-vis provides visualization of circRNA internal structures.
- The tool facilitates the quantification and comparison of circRNA isoform abundance across multiple samples.
Conclusions:
- CIRI-vis addresses the need for a dedicated circRNA visualization tool.
- Enables deeper insights into circRNA biology and transcriptome analysis.
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