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Updated: Dec 30, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
A new alkynol compound from Platycodins folium and its cytotoxicity
Cuizhu Wang1,2, Qinghai Dong2, Fulin Wu2
1Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Abstract:
A new alkynol, platycodynol (1), identified as 2, 3, 9, 13, 14-pentahydroxy-4, 6-tetradecadiyne, along with six known compounds (2-7) were obtained from Platycodins folium for the first time. Their structures were elucidated with infrared (IR), ultraviolet (UV), 1D and 2D nuclear magnetic resonance (NMR) spectroscopic analysis as well as by high resolution electrospray ionization mass spectroscopy (HRESIMS). Platycodynol showed cytotoxicity against S180, A549 and SPC-A-1 cancer cells but no cytotoxicity against normal cells NCTC1469 and HL-7702 by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method.
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