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Published on: June 24, 2019
A new ergostane derivative from the leaves of Heynea trijuga Roxburgh
Shou-Bai Liu1, Zheng Cui1, Hui-Qin Chen2
1Key Laboratory of Genetics and Germplasm Innovation of Tropical Special Forest Trees and Ornamental Plants, Ministry of Education/Key Laboratory of Germplasm Resources of Tropical Special Ornamental Plants of Hainan Province, College of Forestry, Hainan University, Haikou, P. R. China.
Abstract:
During the course of searching for structurally interesting and bioactive compounds, a further chemical investigation of the leaves of Heynea trijuga Roxburgh was performed, which led to the isolation of a new ergostane derivative, named 3β, 4β, 20S-trihydroxyergosta-5, 24(28)-dien-16-one (1), together with five known sterides (3β, 23S)-ergosta-5, 24(28)-diene-3, 23-diol (2), ergosta-5, 24(28)-diene-3β-diol (3), stigmast-5-ene-3β, 7α-diol (4), sitoindoside I (5) and stigmast-3β, 5α, 6β-triol (6). The structure of the new compound was elucidated using a combination of 1 D, 2 D NMR techniques and HR-EI-MS analyses. All the compounds were evaluated for cytotoxic activity against tumor cell line BEL-7402 by MTT method.
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