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Flow Cytometric Characterization of Murine B Cell Development
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It's Hard to Teach an Old B Cell New Tricks

Jenna J Guthmiller1, Patrick C Wilson1

  • 1Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA.

Cell
|January 18, 2020
PubMed

Victora and colleagues challenge current perceptions that memory B cells readily participate in secondary germinal center reactions, allowing further modification of specificity upon reactivation. Rather, naïve B cells are the predominant B cell type that populate secondary germinal centers. This work has important basic immunological and translational implications.

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