Related Experiment Video

Updated: Dec 30, 2025

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

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Sticking it to KRAS: Covalent Inhibitors Enter the Clinic

Frank McCormick1

  • 1UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA; Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.

Cancer Cell
|January 18, 2020
PubMed

Insights

New covalent KRAS G12C inhibitors, AMG 510 and MRTX849, are in clinical trials. Research highlights their development, properties, early data, and combination strategies, signaling progress in Ras pathway targeting.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Development

Background:

  • KRAS mutations are common drivers in various cancers.
  • Targeting KRAS G12C mutations has been a significant challenge in cancer therapy.
  • Recent advancements have led to the development of specific inhibitors.

Purpose of the Study:

  • To review the development and properties of novel covalent KRAS G12C inhibitors.
  • To summarize early clinical data for these targeted agents.
  • To discuss potential combination therapies involving these drugs.

Main Methods:

  • Review of recent scientific literature on AMG 510 and MRTX849.
  • Analysis of preclinical and clinical data.
  • Exploration of emerging therapeutic strategies.

Main Results:

  • AMG 510 and MRTX849 demonstrate selectivity and promising properties.
  • Early clinical data indicate therapeutic potential.
  • Combination therapies are being explored to enhance efficacy.

Conclusions:

  • Covalent KRAS G12C inhibitors represent a breakthrough in targeted cancer therapy.
  • Further research and clinical development are expected.
  • These agents herald a new era in Ras-driven cancer treatment.

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