The Prognostic Importance of TAPSE in Early and in Stable Cardiovascular Diseases

Area of Science:

• Cardiology
• Echocardiography
• Cardiovascular Risk Assessment

Background:

• Identifying predictors of major cardiovascular events (MACES) is crucial, particularly in early and stable cardiovascular diseases.
• Existing methods for risk stratification may not fully capture prognostic information in these patient groups.

Purpose of the Study:

• To comparatively evaluate the prognostic importance of various echocardiographic parameters, including ventricular function and pulmonary hemodynamics, for predicting MACES.
• To determine the independent predictive value of tricuspid annular plane systolic excursion (TAPSE) for cardiovascular outcomes.

Main Methods:

• Prospective study of 369 subjects with cardiovascular risk factors, assessing left and right ventricular function, pulmonary artery pressure (PAP), and pulmonary vascular resistance (PVR) at baseline.
• Follow-up recorded MACES and all-cause mortality.
• Statistical analysis included bivariate and Cox regression models to identify independent predictors.

Main Results:

• Bivariate analysis showed associations between LVEF, TAPSE, MPAP, TRV, PVR, LV diastolic function, and FMR with endpoints.
• Cox analysis revealed LV diastolic function and TAPSE predicted the primary endpoint (MACES and all-cause mortality).
• TAPSE independently predicted the secondary endpoint (MACES).

Conclusions:

• TAPSE is a valuable and independent predictor of MACES and all-cause mortality in patients with early and stable cardiovascular diseases.
• The study supports the implementation of TAPSE in routine clinical practice for enhanced risk stratification.
• Further research may explore the integration of TAPSE with other biomarkers for comprehensive cardiovascular risk assessment.