Related Experiment Video
Updated: Dec 30, 2025

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress
Takamitsu Unoki1, Masahiro Akiyama2, Yoshito Kumagai2
1Department of Basic Medical Sciences, National Institute for Minamata Disease, Minamata, Kumamoto 867-0008, Japan.
Abstract:
Molecular responses mediated by sensor proteins are important for biological defense against electrophilic stresses, such as xenobiotic electrophile exposure. NF-E2-related factor 2 (Nrf2) has an essential function as a master regulator of such cytoprotective molecular responses along with sensor protein Kelch-like ECH-associated protein 1. This review focuses on Nrf2 activation and its involvement with the protective defense systems under electrophilic stresses integrated with our recent findings that reactive sulfur species (RSS) mediate detoxification of electrophiles. The Nrf2 pathway does not function redundantly with the RSS-generating cystathionine γ-lyase pathway, and vice versa.
Related Concept Videos
Other Stress Responses in Bacteria
Regulation of the Unfolded Protein Response
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
The Unfolded Protein Response
Stringent Response in E. coli
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
