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Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Sang Hoon Lee1, Rajiv Bajracharya1, Jeong Youn Min1

  • 1College of Pharmacy, Dongguk University-Seoul, Dongguk-ro 32, Ilsan-Donggu, Goyang 10326, Korea.

Pharmaceutics
|January 19, 2020
PubMed

Insights

Colon targeted drug delivery systems offer a noninvasive approach for treating colonic diseases and delivering sensitive drugs orally. These advanced systems enhance patient compliance and reduce side effects for improved therapeutic outcomes.

Area of Science:

  • Pharmaceutical Sciences
  • Biomedical Engineering

Background:

  • Colon targeted drug delivery systems are crucial for local treatment of colonic diseases, minimizing systemic side effects.
  • They are vital for oral delivery of biologics and macromolecules vulnerable to degradation in the upper gastrointestinal tract.
  • The growing pharmaceutical market for biologics necessitates patient-friendly, noninvasive drug administration methods.

Purpose of the Study:

  • To review recent advancements in colon targeted drug delivery systems.
  • To highlight pharmaceutical applications of these systems, focusing on formulation technologies.
  • To discuss strategies for efficient colonic drug delivery for local and systemic effects.

Main Methods:

  • Exploration of various strategies including pH-dependent, enzyme-triggered, receptor-mediated, and magnetically-driven systems.
  • Review of formulation technologies for colon targeted drug delivery.
  • Analysis of recent advancements and pharmaceutical applications.

Main Results:

  • Colon targeted systems offer improved patient compliance and cost-effectiveness.
  • Various strategies have been developed to achieve efficient drug release in the colon.
  • Formulation technologies are key to successful colon targeted drug delivery.

Conclusions:

  • Colon targeted drug delivery systems are essential for effective treatment of colonic diseases and delivery of macromolecules.
  • Continued research in formulation technologies will enhance the efficacy and patient-friendliness of these systems.
  • Noninvasive colon delivery approaches represent a significant advancement in pharmaceutical drug delivery.
Keywords:
coloncolorectal cancerinflammatory bowel diseasesnoninvasive drug deliveryprotein drugs

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