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Related Concept Videos

Tight Junctions01:29

Tight Junctions

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Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
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Adherens Junctions01:24

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Claudin-1, A Double-Edged Sword in Cancer.

Ajaz A Bhat1, Najeeb Syed1, Lubna Therachiyil2,3

  • 1Division of Translational Medicine, Research Branch, Sidra Medicine, Doha 26999, Qatar.

International Journal of Molecular Sciences
|January 19, 2020
PubMed
Summary

Claudin-1 (CLDN-1) has a complex role in cancer, acting as both a potential tumor promoter and suppressor. Its expression and localization are linked to tumor aggressiveness and patient survival across various cancers.

Keywords:
claudin 1epithelial to mesenchymal transitionmetastasistight junctionstumor

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Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • Claudins are key membrane proteins forming tight junctions in endothelial and epithelial cells.
  • They regulate transport, cell growth, and differentiation, with dysregulation implicated in various diseases.
  • Differential expression and localization of claudins in tumors are critical research areas.

Purpose of the Study:

  • To review the dual role of Claudin-1 (CLDN-1) as a tumor promoter or suppressor in cancers.
  • To analyze CLDN-1 expression patterns and their association with tumor aggressiveness.
  • To investigate CLDN-1's correlation with overall survival and its interaction pathways.

Main Methods:

  • Literature review of CLDN-1's role and localization in cancer.
  • Analysis of The Cancer Genome Atlas (TCGA) data for CLDN-1 expression.
  • Comparison of CLDN-1 expression in normal versus tumor tissues.
  • Pathway interaction analysis for CLDN-1.

Main Results:

  • CLDN-1 exhibits context-dependent roles, acting as both a tumor promoter and suppressor.
  • CLDN-1 expression levels and localization (perijunctional vs. cytoplasmic/nuclear) correlate with tumor aggressiveness and patient survival.
  • TCGA data analysis revealed significant associations between CLDN-1 expression and overall survival across different cancer types.

Conclusions:

  • CLDN-1's role in cancer is complex and tissue-specific, influencing tumor progression and aggressiveness.
  • CLDN-1 localization is a significant factor in determining its impact on cancer.
  • CLDN-1 represents a potential therapeutic target, warranting further investigation into its interaction pathways.