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Bioengineered 3D Models to Recapitulate Tissue Fibrosis.

Marta Sacchi1, Ruchi Bansal2, Jeroen Rouwkema3

  • 1Department of Biomaterials Science and Technology, Technical Medical Centre, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands; Department of Biomechanical Engineering, Technical Medical Centre, Faculty of Engineering Technology, University of Twente, Enschede, The Netherlands.

Trends in Biotechnology
|January 19, 2020
PubMed
Summary
This summary is machine-generated.

Fibrosis causes organ failure, with limited treatments. Advanced 3D human tissue models offer new ways to study fibrosis and screen drugs for liver, kidney, and lung diseases.

Keywords:
biofabricationfibrosisscreeningself-assemblytissue models

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Pathophysiology

Background:

  • Fibrosis is a progressive tissue stiffening leading to organ failure, impacting millions globally.
  • Current treatments for fibrotic diseases are limited, with organ transplantation being the primary option for end-stage cases.
  • Understanding fibrosis mechanisms and developing effective therapies remain critical unmet medical needs.

Purpose of the Study:

  • To review advancements in engineered 3D in vitro human disease models for fibrosis.
  • To highlight the utility of these models for elucidating disease pathogenesis.
  • To discuss their application in high-throughput drug screening for fibrotic conditions.

Main Methods:

  • Focuses on multidisciplinary developments in advanced 3D biomimetic fibrotic tissue models.
  • Incorporates precision manufacturing techniques for model creation.
  • Emphasizes achieving high cellular functionality and relevant biophysical properties.

Main Results:

  • Engineered 3D models recapitulate key aspects of fibrotic tissue pathophysiology.
  • These models provide platforms for mechanistic studies of fibrosis.
  • They enable reproducible, high-throughput drug screening for potential therapeutics.

Conclusions:

  • Advanced 3D biomimetic models represent a significant breakthrough in fibrosis research.
  • These models offer improved understanding and therapeutic development for liver, kidney, and lung fibrosis.
  • They pave the way for novel treatment strategies against fibrotic diseases.