Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malignant osteoporosis and defective immunoregulation.

K R Rubin1, M Ballow, R Baron

  • 1Department of Pediatrics and Medicine, University of Connecticut, Farmington 06032.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|October 1, 1988
PubMed
Summary

This study describes a rare case of severe osteopenia and recurrent fractures in a child linked to abnormal T cell activity and increased osteoclast function, suggesting a new congenital immune and bone disorder.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ethical guidelines for publication of research.

Calcified tissue international·2016
Same author

Cell and matrix response of temporomandibular cartilage to mechanical loading.

Osteoarthritis and cartilage·2015
Same author

Response of knee fibrocartilage to joint destabilization.

Osteoarthritis and cartilage·2015
Same author

Causes of secondary osteoporosis.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2013
Same author

A novel GFP reporter mouse reveals Mustn1 expression in adult regenerating skeletal muscle, activated satellite cells and differentiating myoblasts.

Acta physiologica (Oxford, England)·2013
Same author

Importance of bone mineral density measurements in evaluating fragility bone fracture risk in Asian Indian men.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010

Area of Science:

  • Immunology
  • Bone Biology
  • Pediatric Endocrinology

Background:

  • The relationship between immune cells and osteoclasts is partially understood.
  • Clinical disorders linking these systems require further elucidation.

Observation:

  • A 29-month-old girl presented with recurrent infections and multiple fractures.
  • Immune evaluation revealed absent antibodies and decreased immunoglobulin production, with normal B cell function but increased suppressor T cell activity.
  • Bone evaluation showed diffuse osteopenia, normal mineralization, and increased atypical osteoclasts, with hypercalciuria.

Findings:

  • The patient exhibited severe osteopenia with increased bone resorption and decreased bone formation.
  • Abnormal T cell immunoregulation was identified as a key feature.

Related Experiment Videos

  • Calcitonin therapy reduced hypercalciuria.

    • Implications:

    • This case may represent a novel congenital disorder linking immune dysfunction and bone metabolism.
    • Further research is needed to understand the common pathway between immune cells and osteoclast activity.
    • This finding highlights the complex interplay between the immune and skeletal systems.