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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Related Experiment Video

Updated: Dec 30, 2025

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

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Colorectal cancer and trace elements alteration.

Jovan T Juloski1, Aleksandar Rakic2, Vladica V Ćuk1

  • 1Zvezdara Medical University Center, Surgery Clinic "Nikola Spasić", Dimitrija Tucovica 161, 11000 Belgrade, Serbia.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|January 19, 2020
PubMed
Summary

This study found significant differences in trace element concentrations, including sodium, potassium, and zinc, between colorectal cancer tissues and healthy tissues. The copper/zinc ratio was notably higher in colorectal cancer patients, especially in advanced stages.

Keywords:
Colorectal cancerCu/Zn ratioHealthy tissueTrace elements

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Area of Science:

  • Biochemistry
  • Oncology
  • Environmental Health

Background:

  • Trace elements are crucial for physiological processes, and their dysregulation is linked to various diseases, including cancer.
  • Altered elemental concentrations can cause cellular damage, DNA injury, and oxidative stress.
  • Previous research indicates a connection between elemental imbalances and cancer development.

Purpose of the Study:

  • To investigate and quantify differences in trace element concentrations between colorectal adenocarcinoma and adjacent healthy intestinal tissues.
  • To explore the potential of trace element profiles as biomarkers for colorectal cancer.
  • To establish a baseline for trace element analysis in colorectal cancer within the Balkan region.

Main Methods:

  • Inductively coupled plasma mass spectrometry (ICP-MS) was employed for elemental analysis.
  • Samples were collected from 59 participants, including colon tumor tissue and adjacent healthy mucosa.
  • Standard diagnostic procedures were used for patient diagnosis and sample acquisition.

Main Results:

  • Significant differences in concentrations of Na, K, Mg, Ca, Cu, Zn, Se, Mn, Cd, Cr, and Hg were observed between cancerous and healthy tissues.
  • The copper/zinc (Cu/Zn) tissue ratio was significantly elevated in colorectal cancer (CRC) patients compared to healthy individuals.
  • A higher Cu/Zn ratio correlated with advanced stages of colorectal cancer.

Conclusions:

  • The study highlights specific trace element alterations associated with colorectal cancer.
  • The elevated Cu/Zn ratio may serve as a potential indicator for CRC progression.
  • Findings provide valuable insights into elemental imbalances in the Balkan population's colorectal cancer, considering regional lifestyle and environmental factors.