Related Experiment Video

Updated: Dec 30, 2025

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
06:09

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

16.6K

Association between impaired cutaneous microvascular endothelial function and lectin-like oxidized low-density

Jian Zhao1, Yanda Zhang1, Zhigang Huang1

  • 1Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Microvascular Research
|January 20, 2020
PubMed

Insights

Patients with coronary slow flow (CSF) exhibit impaired cutaneous microvascular endothelial function. This dysfunction is linked to elevated levels of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1).

Area of Science:

  • Cardiovascular Medicine
  • Microvascular Physiology
  • Biomarkers

Background:

  • Coronary slow flow (CSF) is increasingly recognized as a systemic microvascular disorder.
  • The status of cutaneous microvascular endothelial function in CSF patients remains incompletely understood.
  • This study investigates the link between CSF and skin microvascular health.

Purpose of the Study:

  • To determine if cutaneous microvascular endothelial function is impaired in patients with coronary slow flow (CSF).
  • To examine the correlation between impaired cutaneous microvascular endothelial function and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in CSF patients.

Main Methods:

  • 39 CSF patients and 45 controls were assessed using the thrombolysis in myocardial infarction frame count (TFC) for coronary flow.
  • Cutaneous blood flow responses to passive limb movement (PORH) were measured using a laser Doppler flowmetry system (LSCI).
  • Serum levels of soluble LOX-1 (sLOX-1) were quantified in all participants.

Main Results:

  • CSF patients showed significantly reduced PORH-induced vasodilation compared to controls (P < 0.001).
  • Serum sLOX-1 levels were significantly higher in CSF patients (P < 0.001) and correlated positively with mean TFC.
  • Impaired vasodilation in CSF patients negatively correlated with serum sLOX-1 levels (r = -0.588, P < 0.001).

Conclusions:

  • Cutaneous microvascular endothelial function is demonstrably impaired in patients with coronary slow flow (CSF).
  • Increased expression of LOX-1 is closely associated with this impaired microvascular function in CSF.
  • These findings highlight a potential systemic microvascular component in CSF.
Abstract

Keywords:
Coronary slow flowCutaneous microvascular endothelial functionLaser speckle contrast imagingLectin-like oxidized low-density lipoprotein receptor-1Post-occlusive reactive hyperemia

More Related Videos

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

18.5K
A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

16.7K

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
309
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
247
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
805
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
701
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
282