Oscillotherapeutics - Time-targeted interventions in epilepsy and beyond
Yuichi Takeuchi1, Antal Berényi2
1MTA-SZTE 'Momentum' Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged, 6720, Hungary; Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467-8603, Japan.
Neuroscience Research
|January 20, 2020
Summary
Brain oscillations are vital for function, and their disruption underlies many neurological and psychiatric disorders. Studying these pathological brain oscillations may offer biomarkers and therapeutic targets.
Area of Science:
- Neuroscience
- Neurology
- Psychiatry
Background:
- Normal brain oscillations are crucial for motor control and cognitive functions.
- Disruptions in brain oscillatory activity are common in diverse neurological and psychiatric conditions such as epilepsy, Parkinson's disease, Alzheimer's disease, schizophrenia, anxiety/trauma-related disorders, major depressive disorders, and drug addiction.
- These disorders, despite varied symptoms and causes, share common oscillation defects.
Purpose of the Study:
- To highlight the role of pathological brain oscillations as a unifying feature across neurological and psychiatric disorders.
- To explore the potential of studying these oscillations as biomarkers for disease symptoms.
- To investigate the application of advanced brain stimulation technologies for therapeutic interventions.
Main Methods:
- Review of recent advances in neuronal activity recording and analysis techniques.
- Examination of emerging brain stimulation technologies for targeted interventions.
- Analysis of pathological oscillations in the context of specific neurological and psychiatric disorders.
Main Results:
- Technical advancements enable detailed study of pathological brain oscillations.
- These oscillations can serve as potential biomarkers for disease symptoms.
- Brain stimulation technologies offer new avenues for symptom regulation.
Conclusions:
- Pathological brain oscillations represent a common underlying mechanism in a wide range of neurological and psychiatric disorders.
- Studying these oscillatory defects provides insights into disease mechanisms and symptom biomarkers.
- Advanced neurostimulation techniques hold promise for targeted therapeutic interventions in these conditions.
Keywords:
Closed-loop interventionEpilepsyNeuromodulationOscillationOscillopathyOscillotherapeuticsPsychiatric disordersTranscranial electrical stimulationMore Related Videos
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