Related Experiment Video
Updated: Dec 30, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Associations between Seven Common Cytokine Gene Polymorphisms and Coronary Artery Disease: Evidence from a
Pan Yang1,2, Junli Liu3, Jinqiu Xiao4
1Emergency Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Background:
Associations of polymorphisms in interferon-gamma (IFNG), interleukin-10 (IL-10), and interleukin-18 (IL-18) with coronary artery disease (CAD) have already been investigated by many studies, yet the findings of these studies have been somewhat inconsistent.
Objectives:
The aim of this meta-analysis was to better clarify associations between polymorphisms in IFNG/IL-10/IL-18 and CAD by combing the results of all relevant articles.
Methods:
Eligible articles were searched from PubMed, EMBASE, WOS, and CNKI. We used Review Manager to combine the results of indi-vidual studies.
Results:
Fifty-one studies were included in this meta-analysis. Combined results revealed that IFNG rs243056, IL-10rs1800871, IL-18rs187238, IL-18rs1946518, and IL-18rs1946519 polymorphisms were all significantly associated with CAD in the general population. We also obtained similar significant results for IFNG rs243056, IL-10rs1800871, IL-10 rs1800896, IL-18rs187238, IL-18rs1946518, and IL-18rs1946519 polymorphisms in Asians in further subgroup analyses.
Conclusions:
Collectively, this meta-analysis proved that IFNG rs243056, IL-10rs1800871, IL-10 rs1800896, IL-18rs187238, IL-18rs1946518, and IL-18rs1946519 polymorphisms may confer susceptibility to CAD for Asians.
More Related Videos
08:51Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
11:00Multiplex Cytokine Profiling of Stimulated Mouse Splenocytes Using a Cytometric Bead-based Immunoassay Platform
Published on: November 9, 2017
Related Concept Videos
Coronary Artery Disease I: Introduction
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Coronary Artery Disease II: Pathophysiology
Single Nucleotide Polymorphisms-SNPs
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Coronary Artery Disease III: Clinical Manifestations