Single Dose of Doxycycline for the Prevention of Tick-borne Relapsing Fever
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Updated: Dec 30, 2025

04:47
Author Spotlight: Controlled Human Exposure Model for Tick Research and Lyme Disease Studies
Published on: December 1, 2023
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Yoav Binenbaum1,2,3, Ronen Ben-Ami3,4, Gad Baneth5
1Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Abstract:
The current postexposure prophylaxis regimen for tick-borne relapsing fever (TBRF) consists of 5 days' doxycycline. In this observational study of 77 spelunkers at high risk for TBRF, a single dose of 100 mg doxycycline taken up to 72 hours after exposure to ticks was 100% effective in preventing the disease.

