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Association between cardiovascular risk factors and stage 1 hypertension defined by the 2017 ACC/AHA guidelines

Xing Zhen Liu1, Dong Shui Chen1, Fu Ping Di1

  • 1The First Convalescence Area, Hangzhou Aeronautical Sanatorium of Chinese Air Force , Hangzhou, China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|January 21, 2020
PubMed

Insights

Stage 1 hypertension (130-139/80-89 mmHg) in China is linked to higher cardiovascular risk factors. Targeted interventions for abdominal obesity, elevated fasting plasma glucose, and high triglycerides are crucial for managing this condition.

Area of Science:

  • Cardiology
  • Public Health
  • Preventive Medicine

Background:

  • The 2017 ACC/AHA guidelines define stage 1 hypertension as 130-139/80-89 mmHg.
  • This definition impacts a significant portion of the adult population.
  • Understanding associated cardiovascular risk factors (CRFs) is vital for public health strategies in China.

Purpose of the Study:

  • To investigate the association between CRFs and newly defined stage 1 hypertension in the Chinese adult population.
  • To identify specific CRFs that contribute to stage 1 hypertension.
  • To inform targeted interventions for hypertension prevention and management.

Main Methods:

  • Analysis of data from 84,489 adults with blood pressure <140/90 mmHg.
  • Calculation of 10-year cardiovascular disease (CVD) risk using the China-PAR equation.
  • Logistic regression analysis to determine the association between CRFs and stage 1 hypertension.

Main Results:

  • Individuals with stage 1 hypertension (130-139/80-89 mmHg) exhibited higher mean CRFs, metabolic abnormalities, and 10-year CVD risk compared to those with lower BP.
  • Increased odds of stage 1 hypertension were significantly associated with waist circumference (OR 1.362), fasting plasma glucose (OR 1.264), and triglycerides (OR 1.331).
  • Other CRFs did not show a significant association with stage 1 hypertension in this cohort.

Conclusions:

  • Stage 1 hypertension in China is associated with a clustering of cardiovascular risk factors.
  • Abdominal obesity, elevated fasting plasma glucose, and hypertriglyceridemia are key modifiable risk factors.
  • Multidisciplinary and targeted interventions are necessary to manage these CRFs in individuals with stage 1 hypertension.
Abstract

Keywords:
Hypertensioncardiovascular diseasedyslipidemiahyperuricemiaobesity

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