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Impacts of hippocampal blood flow on changes in left ventricular wall thickness in patients with chronic heart

Hideaki Suzuki1, Yasuharu Matsumoto1, Koichiro Sugimura1

  • 1Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

International Journal of Cardiology
|January 21, 2020
PubMed

Insights

Altered hippocampal perfusion in chronic heart failure (CHF) patients may worsen cardiac structure through increased depressive symptoms. This study reveals a link between brain blood flow, mood, and heart changes in CHF.

Area of Science:

  • Neurocardiology
  • Psychocardiology
  • Medical imaging

Background:

  • Depressive symptoms are linked to increased mortality and hospitalization in chronic heart failure (CHF) patients.
  • The underlying mechanisms connecting depression and cardiac issues in CHF remain unclear.
  • Hippocampal perfusion alterations are implicated in depressive symptoms.

Purpose of the Study:

  • To investigate the association between hippocampal perfusion and cardiac structure/function changes in CHF patients.
  • To explore if altered hippocampal blood flow relates to depressive symptoms and cardiac alterations.
  • To examine the neural substrate of depressive symptoms in relation to cardiac remodeling in CHF.

Main Methods:

  • Utilized baseline data from 70 CHF patients in the Brain Assessment and Investigation in Heart Failure Trial (B-HeFT).
  • Assessed hippocampal cerebral blood flow (CBF), Geriatric Depression Scale (GDS) scores, and echocardiographic parameters.
  • Employed voxel-wise regression and structural equation modeling to analyze relationships over a 3.1-year follow-up.

Main Results:

  • Baseline anterior hippocampal CBF negatively correlated with changes in left ventricular posterior wall thickness (PWT).
  • Depressive symptoms positively correlated with baseline anterior CBF and negatively with PWT changes.
  • Found direct effects of hippocampal CBF on PWT thinning and indirect effects mediated by depressive symptoms.

Conclusions:

  • Provides the first evidence linking altered hippocampal perfusion to cardiac structural changes in CHF patients.
  • Suggests that changes in hippocampal blood flow may drive cardiac alterations via increased depressive symptoms.
  • Highlights a potential neurobiological pathway connecting brain function, mood, and cardiac health in chronic heart failure.
Abstract

Keywords:
Cardiac remodelingCerebral blood flowHeart failureHeart-brain axisHippocampus

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