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Are We Ill Because We Age?

Tamas Fulop1, Anis Larbi2,3,4, Abdelouahed Khalil1

  • 1Geriatrics Division, Department of Medicine, Research Center on Aging, University of Sherbrooke, Sherbrooke, QC, Canada.

Frontiers in Physiology
|January 21, 2020
PubMed
Summary
This summary is machine-generated.

The growing elderly population faces increased chronic age-related diseases (ARDs). Geroscience views aging as a disease, but a lack of definition prevents treating aging itself. Instead, focus on optimizing individual adaptations for better healthspan.

Keywords:
adaptationage related diseasesagingaging as a diseaseanti-aging medicinefunctional healthspangeroscienceoptimization of aging

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Area of Science:

  • Gerontology
  • Public Health
  • Biomedical Science

Background:

  • Aging populations present significant health and socioeconomic challenges.
  • Increased life expectancy correlates with a rise in chronic age-related diseases (ARDs).
  • Geroscience proposes aging as the root cause of ARDs.

Purpose of the Study:

  • To explore the concept of geroscience and its implications for treating aging.
  • To critically evaluate whether aging should be considered a disease.
  • To identify alternative approaches for managing age-related health issues.

Main Methods:

  • Literature review and conceptual analysis of geroscience.
  • Examination of the definition and causes of aging.
  • Discussion of the challenges in translating geroscience into medical practice.

Main Results:

  • Geroscience posits aging as a common cause of ARDs, suggesting it be treated as a disease.
  • A lack of consensus on the definition, causes, and targets for aging interventions makes treating it as a disease problematic.
  • Aging is not a disease but can be optimized at an individual level.

Conclusions:

  • Treating aging itself as a disease is currently not feasible due to definitional gaps.
  • Focus should shift from treating aging as a disease to optimizing individual healthspan.
  • Interventions should aim to improve functional health through adaptation and change.