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Deep brain stimulation for Tourette's syndrome.

Wenying Xu1, Chencheng Zhang1, Wissam Deeb2

  • 11Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Hospital, 197 Ruijin Er Road, Shanghai, 200025 China.

Translational Neurodegeneration
|January 21, 2020
PubMed
Summary

Deep brain stimulation (DBS) offers a promising treatment for severe Tourette syndrome (TS) when other therapies fail. Research is advancing DBS for refractory TS, focusing on patient selection, ethics, and optimizing outcomes.

Keywords:
Adaptive close loopCapsulotomyConnectivityDeep brain stimulationTourette syndrome

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Area of Science:

  • Neuroscience
  • Neurology
  • Psychiatry

Background:

  • Tourette syndrome (TS) is a childhood-onset disorder with motor and vocal tics, often co-occurring with psychiatric conditions.
  • Standard treatments for TS are insufficient for some patients, leading to chronic, disabling symptoms.
  • Deep brain stimulation (DBS) targeting basal ganglia-thalamocortical networks is an emerging option for refractory TS.

Purpose of the Study:

  • To review the challenges, advancements, and potential of DBS for treating severe, intractable Tourette syndrome.
  • To summarize clinical study results and discuss ethical considerations for pediatric DBS treatment.
  • To enhance understanding of DBS feasibility, safety, selection, and effectiveness in select TS cases.

Main Methods:

  • Review of clinical studies on DBS for Tourette syndrome.
  • Discussion of patient selection criteria and DBS target identification.
  • Analysis of ethical issues related to pediatric DBS treatment.

Main Results:

  • DBS shows promise for refractory Tourette syndrome, including cases with comorbidities.
  • Key challenges include patient/target selection, pediatric ethical concerns, and outcome optimization.
  • Recent guidelines address surgical treatment recommendations for refractory TS.

Conclusions:

  • DBS is a potential intervention for select patients with severe, medically intractable Tourette syndrome.
  • Further research is needed to optimize DBS treatment and improve patient outcomes.
  • Addressing ethical concerns is crucial for the advancement of DBS in pediatric TS patients.