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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Accessory Structures of the Skin: Sebaceous Glands01:21

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Cutaneous sebaceous carcinoma.

Albert Wu1, Saul N Rajak2, Shyamala C Huilgol1,3

  • 1Department of Dermatology, Royal Adelaide Hospital, The University of Adelaide, Adelaide, South Australia, Australia.

The Australasian Journal of Dermatology
|January 21, 2020
PubMed
Summary
This summary is machine-generated.

Cutaneous sebaceous carcinoma, a rare head and neck cancer, often mimics benign conditions, leading to delayed treatment. Genetic insights are guiding new targeted therapies for this recurring cancer.

Keywords:
Lynch syndromeMohsMuir-Torre syndromebasal cell carcinomaskin cancersquamous cell carcinoma

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Area of Science:

  • Dermatology
  • Oncology
  • Genetics

Background:

  • Cutaneous sebaceous carcinoma primarily affects the head and neck.
  • It frequently recurs and metastasizes.
  • Often misdiagnosed as benign skin conditions, leading to improper management.

Purpose of the Study:

  • To review the clinical presentation, diagnosis, and management of cutaneous sebaceous carcinoma.
  • To highlight the importance of high clinical suspicion for early detection.
  • To discuss recent genetic findings and their implications for targeted therapy.

Main Methods:

  • Literature review of existing evidence on sebaceous carcinoma.
  • Analysis of genetic data suggesting distinct mutational groups.
  • Discussion of diagnostic and staging investigations, including Muir-Torre syndrome screening.
  • Evaluation of current treatment options and management recommendations.

Main Results:

  • Sebaceous carcinoma has a high recurrence and metastasis rate.
  • It can occur with similar frequency in Asian and white populations.
  • Genetic heterogeneity indicates potential for personalized treatment strategies.
  • Muir-Torre syndrome should be considered in the diagnostic workup.

Conclusions:

  • High index of suspicion is crucial for early diagnosis of sebaceous carcinoma.
  • Genetic profiling is essential for understanding disease subtypes and guiding targeted therapies.
  • Comprehensive staging and Muir-Torre syndrome evaluation are recommended post-diagnosis.
  • Evidence-based management strategies are vital for improving patient outcomes.