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GRIN2B Gene Polymorphism in Chronic Ketamine Users.

Ni Fan1, Lina An1, Minling Zhang1

  • 1Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University, 36 Mingxin Road, Liwan District, Guangzhou, Guangdong, 510370, China.

The American Journal on Addictions
|January 21, 2020
PubMed
Summary
This summary is machine-generated.

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Genetic variations in the N-methyl-D-aspartate receptor 2B (GRIN2B) gene are associated with ketamine use patterns. GRIN2B gene polymorphism may influence ketamine abuse susceptibility and onset.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Chronic ketamine use is a growing public health concern.
  • Understanding the genetic factors influencing ketamine abuse is crucial for developing targeted interventions.
  • The N-methyl-D-aspartate receptor 2B (GRIN2B) gene is a potential candidate for mediating ketamine's effects.

Purpose of the Study:

  • To investigate the association between GRIN2B gene polymorphisms and ketamine use conditions.
  • To explore the relationship between GRIN2B gene variants and psychopathological symptoms in chronic ketamine users.

Main Methods:

  • Genotyping of four single nucleotide polymorphisms (SNPs) in the GRIN2B gene (rs1805502, rs7301328, rs890, rs1806201).
  • Recruitment of 231 subjects, including 151 male chronic ketamine users and 80 controls.
Keywords:
GRIN2Bketamine usesingle nucleotide polymorphisms

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  • Assessment of psychopathological symptoms using validated scales (PANSS, BDI, BAI).

    • Main Results:

    • The CC genotype of rs1806201 was less frequent in ketamine users, while the T allele was more frequent, suggesting a potential protective role.
    • Individuals with TT and CC genotypes of rs1806201 exhibited an earlier onset of ketamine use.
    • The GG genotype of rs7301328 was associated with a higher daily ketamine consumption dose.

    Conclusions:

    • GRIN2B gene polymorphism may influence susceptibility to ketamine abuse.
    • Specific GRIN2B variants are linked to earlier onset and higher consumption of ketamine.
    • Further research is warranted to elucidate the precise mechanisms underlying GRIN2B's role in ketamine addiction.