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Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
09:11

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

Published on: August 23, 2016

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Zika virus in the eye of the cytokine storm

Christopher Maucourant1, Gabriel Andrade Nonato Queiroz2, Assia Samri1

  • 1Sorbonne Universités, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.

European Cytokine Network
|January 21, 2020
PubMed

Insights

Zika virus (ZIKV) infection, typically mild, is linked to Guillain-Barré syndrome and congenital microcephaly. Recent research advances understanding of ZIKV

Area of Science:

  • Virology
  • Immunology
  • Neurology

Background:

  • Zika virus (ZIKV) is an emerging arbovirus causing mosquito-borne illness.
  • While often mild, ZIKV is associated with Guillain-Barré syndrome and congenital microcephaly.
  • Significant scientific progress has been made in understanding ZIKV's features.

Purpose of the Study:

  • To review recent advances in ZIKV research.
  • To highlight the role of cytokines and chemokines in ZIKV infection.
  • To discuss potential links between ZIKV and pathogenesis.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of clinical, virological, and immunological data.
  • Discussion of physiopathological mechanisms.

Main Results:

  • Advances in understanding ZIKV's clinical manifestations.
  • Insights into ZIKV's virology and immunology.
  • Identification of potential pathogenic pathways involving cytokines and chemokines.

Conclusions:

  • Cytokines and chemokines play a crucial role in ZIKV pathogenesis.
  • Further research is needed to fully elucidate ZIKV's impact.
  • Understanding these mechanisms may lead to therapeutic strategies.
Keywords:
ChemokinesCytokinesFlavivirusGuillain-Barré syndromeMicrocephalyZika virus

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