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Updated: Dec 30, 2025
In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
Published on: February 25, 2022
Pseudo-spiral sampling and compressed sensing reconstruction provides flexibility of temporal resolution in
Lukas M Gottwald1, Eva S Peper1, Qinwei Zhang1
1Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands.
Introduction:
Time-resolved three-dimensional phase contrast MRI (4D flow) of aortic blood flow requires acceleration to reduce scan time. Two established techniques for highly accelerated 4D flow MRI are k-t principal component analysis (k-t PCA) and compressed sensing (CS), which employ either regular or random k-space undersampling. The goal of this study was to gain insights into the quantitative differences between k-t PCA- and CS-derived aortic blood flow, especially for high temporal resolution CS 4D flow MRI.
Methods:
The scan protocol consisted of both k-t PCA and CS accelerated 4D flow MRI, as well as a 2D flow reference scan through the ascending aorta acquired in 15 subjects. 4D flow scans were accelerated with factor R = 8. For CS accelerated scans, we used a pseudo-spiral Cartesian sampling scheme, which could additionally be reconstructed at higher temporal resolution, resulting in R = 13. 4D flow data were compared with the 2D flow scan in terms of flow, peak flow and stroke volume. A 3D peak systolic voxel-wise velocity and wall shear stress (WSS) comparison between k-t PCA and CS 4D flow was also performed.
Results:
The mean difference in flow/peak flow/stroke volume between the 2D flow scan and the 4D flow CS with R = 8 and R = 13 was 4.2%/9.1%/3.0% and 5.3%/7.1%/1.9%, respectively, whereas for k-t PCA with R = 8 the difference was 9.7%/25.8%/10.4%. In the voxel-by-voxel 4D flow comparison we found 13.6% and 3.5% lower velocity and WSS values of k-t PCA compared with CS with R = 8, and 15.9% and 5.5% lower velocity and WSS values of k-t PCA compared with CS with R = 13.
Conclusion:
Pseudo-spiral accelerated 4D flow acquisitions in combination with CS reconstruction provides a flexible choice of temporal resolution. We showed that our proposed strategy achieves better agreement in flow values with 2D reference scans compared with using k-t PCA accelerated acquisitions.
