COvalent monolayer patterns in Microfluidics by PLasma etching Open Technology - COMPLOT
Stan B J Willems1, Jaccoline Zegers2, Anton Bunschoten3
1Laboratory of BioNanoTechnology, Wageningen University and Research, Bornse Weilanden 9, 6708 WG Wageningen, the Netherlands. vittorio.saggiomo@wur.nl and Wetsus, European Centre of Excellence for Sustainable Water Technology, Oostergoweg 9, 8911 MA Leeuwarden, the Netherlands and Interventional Molecular Imaging, Department of Radiology, Leiden University and Medical Centre, 2300 RC Leiden, the Netherlands.
Abstract:
Plasma microcontact patterning (PμCP) and replica molding were combined to make PDMS/glass microfluidic devices with β-cyclodextrin (β-CD) patterns attached covalently on the glass surface inside microchannels. The supramolecular reactivity, reusability and association constant of β-CD with Cy5-Ad2 was tested by analyzing signal-to-noise ratios of patterns vs. spacing with fluorescence microscopy.
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