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This study developed patterned microfluidic devices using plasma microcontact patterning and replica molding. These devices feature covalently attached beta-cyclodextrin (β-CD) for molecular recognition applications.

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Area of Science:

  • Biomaterials Science
  • Microfluidics
  • Surface Chemistry

Background:

  • Microfluidic devices offer precise control over small fluid volumes.
  • Surface modification is crucial for creating functional microfluidic interfaces.
  • Beta-cyclodextrin (β-CD) is a host molecule with applications in molecular recognition and sensing.

Purpose of the Study:

  • To develop a method for creating covalently patterned beta-cyclodextrin (β-CD) surfaces within microfluidic channels.
  • To investigate the supramolecular reactivity and reusability of these β-CD patterns.
  • To determine the association constant of β-CD with a model guest molecule.

Main Methods:

  • Combined plasma microcontact patterning (PμCP) and replica molding to fabricate polydimethylsiloxane (PDMS)/glass microfluidic devices.
  • Covalently attached β-CD patterns onto the glass surface inside microchannels.
  • Utilized fluorescence microscopy to analyze signal-to-noise ratios of patterns versus spacing.

Main Results:

  • Successfully fabricated microfluidic devices with covalently immobilized β-CD patterns.
  • Demonstrated the supramolecular reactivity of the β-CD patterns with a Cy5-labeled adamantane dimer (Cy5-Ad2).
  • Quantified the reusability and determined the association constant of the β-CD/Cy5-Ad2 interaction.

Conclusions:

  • Plasma microcontact patterning is an effective technique for creating functional β-CD surfaces in microfluidics.
  • The developed β-CD patterned microfluidic devices show promise for molecular recognition and sensing applications.
  • The method allows for precise control over pattern features and demonstrates good reusability.