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Updated: Dec 30, 2025

Optimization of the Cuff Technique for Murine Heart Transplantation
Published on: June 26, 2020
First Successful Open-Heart Surgery Utilizing Cross-Circulation in 1954
Tinen L Iles1, Mikayle A Holm2, Andrew D Calvin3
1Department of Surgery, University of Minnesota, Minneapolis, Minnesota.
Abstract:
A pioneering surgeon at the University of Minnesota, Dr C. Walton Lillehei, is still considered the "father of open-heart surgery". Dr Lillehei and his surgical team performed the first open-heart operations utilizing cross-circulation, including the first successful ventricular septal defect closure on a 3-year-old boy. Before his death at age 67, this patient arranged to donate his body to the University of Minnesota's Anatomy Bequest program. We describe this patient's medical history, and present unique images of internal/external cardiac anatomies and implanted devices obtained via direct visualizations, computed tomography, and fluoroscopy post-mortem. Additionally, we present computational models and 3-dimensional printed models.

