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Delayed immune dysfunction following hemorrhagic shock and resuscitation
M A Croce1, T C Fabian, K A Kudsk
1Department of Surgery, University of Tennessee, Memphis.
The American Surgeon
|December 1, 1988
Summary
Hemorrhagic shock depresses immune function in rats, especially those without a spleen. Hetastarch resuscitation did not affect reticuloendothelial system function in this delayed immune response study.
Area of Science:
- Immunology
- Physiology
- Surgical Research
Background:
- Hemorrhagic shock is known to impair immune function.
- The delayed effects of shock and resuscitation on the immune system require further investigation.
- The reticuloendothelial system (RES) plays a crucial role in immune surveillance.
Purpose of the Study:
- To evaluate the delayed immune response following hemorrhagic shock in rats.
- To assess the impact of splenectomy on immune function after shock.
- To investigate the effect of hetastarch resuscitation on RES function post-shock.
Main Methods:
- Rats underwent hemorrhagic shock and resuscitation with hetastarch or lactated Ringer's, with or without splenectomy.
- One week post-resuscitation, animals were challenged with Streptococcus pneumoniae.
- Bacterial loads in blood and tissues were quantified via culture.
Main Results:
- No significant difference in RES function was observed between hetastarch and lactated Ringer's groups.
- Shocked, nonsplenectomized rats exhibited higher bacterial counts compared to controls, indicating depressed immune function.
- Splenectomized rats showed no significant differences between shocked and control groups, suggesting splenectomy exacerbates immune dysfunction.
Conclusions:
- Delayed immune function is impaired following hemorrhagic shock in rats, particularly in nonsplenectomized individuals.
- Splenectomy results in more severe immune dysfunction than hemorrhagic shock alone.
- Hetastarch resuscitation does not appear to alter delayed RES function in nonsplenectomized rats.