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In Vitro Thrombosis Test for Ventricular Assist Devices
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In vitro testing of a funnel-shaped tip catheter model to decrease clot migration during mechanical thrombectomy.

Yasemin Tanyildizi1, Emily Payne2, Tiemo Gerber3

  • 1University Medical Center Mainz, Department of Neuroradiology, Langenbeckstraße 1, 55131, Mainz, Germany. y.tanyildizi@gmx.net.

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|January 22, 2020
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Summary
This summary is machine-generated.

A novel funnel-shaped catheter tip significantly improves mechanical thrombectomy (MT) success rates by preventing clot migration. This new design offers a promising solution to a key limitation in stroke treatment.

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Area of Science:

  • Endovascular Therapy
  • Medical Device Innovation
  • Cerebrovascular Surgery

Background:

  • Mechanical thrombectomy (MT) is a critical treatment for acute ischemic stroke.
  • Clot migration during MT, often due to distal access catheter (DAC) tip design, limits procedure effectiveness.
  • Current cylindrical DAC tips may cause thrombus dislodgement during stent-retriever retrieval.

Purpose of the Study:

  • To evaluate the proof-of-concept for a novel funnel-shaped DAC tip.
  • To compare the efficacy of a funnel-shaped tip against a traditional cylindrical tip in preventing clot migration during MT.
  • To assess the impact of DAC tip design on first-pass recanalization rates in an in vitro model.

Main Methods:

  • An in vitro experimental setup using a self-made vessel model and porcine blood clots was developed.
  • Two DAC models were tested: one with a funnel-shaped tip and one with a cylindrical tip.
  • Mechanical thrombectomy was performed 20 times for each model using two different stent-retrievers.

Main Results:

  • The funnel-shaped DAC tip achieved a 90% first-pass success rate with both tested stent-retrievers.
  • The cylindrical DAC tip demonstrated lower first-pass success rates: 50% with a smaller stent-retriever and 60% with a larger one.
  • The funnel-shaped tip showed a significantly better recanalization rate compared to the cylindrical tip.

Conclusions:

  • The funnel-shaped DAC tip design shows superior performance in preventing clot migration and improving MT success.
  • This innovative design presents a feasible approach to overcome a significant limitation in mechanical thrombectomy.
  • Further development of a prototype catheter with a funnel-shaped tip is warranted based on these promising experimental results.