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Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis
Craig A Beam1, Clive Wasserfall2, Alyssa Woodwyk3
1Department of Biomedical Sciences, Western Michigan University Homer W. Stryker M.D. School of Medicine, Kalamazoo Michigan, USA. craig.beam@med.wmich.edu.
Scientific Reports
|January 22, 2020
Summary
Daily immune system rhythms significantly impact regulatory T-cells and CD8+ memory cells, revealing a dynamic, interconnected immune wave-field. This study maps daily immune variations and correlations for future research.
Area of Science:
- Immunology
- Systems Biology
- Chronobiology
Background:
- The human peripheral immune system exhibits daily variations.
- Understanding these variations is crucial for fundamental immunology research.
Purpose of the Study:
- To conduct a comprehensive systems immunology analysis of daily variation in the normal human peripheral immune system.
- To identify circadian rhythmicity's impact on immune cell populations and their correlations.
- To uncover the core set of immune factors with persistent relational structures.
Main Methods:
- Systems immunology analysis of daily peripheral immune system data.
- Assessment of circadian rhythmicity's contribution to variation in B-cells, CD4+ subsets, CD4+ regulatory T-cells, and CD8+ central memory cells.
- Identification of ubiquitously correlated immune factors and a core set resistant to circadian variation removal.
Main Results:
- Circadian rhythmicity significantly impacts CD4+ regulatory T-cell (over 25%) and CD8+ central memory cell (over 50%) variation.
- Phase alignment was observed within functional phenotypes of circadian rhythmicity.
- A core set of immune factors, including CD8+ subpopulations and NK cells, showed persistent correlations.
- Previously described mechanistic relationships appeared as phase shifts in rhythmic patterns.
Conclusions:
- The peripheral immune system functions as a dynamic, interconnected wave-field with daily repeating patterns.
- Data provides a comprehensive inventory of synchronization and correlation within the immune wave-field.
- Encourages further laboratory testing of discovered mechanistic relationships.
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