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Updated: Dec 30, 2025

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

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Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers

Gabriel G Malouf1,2,3, Ronan Flippot4, Yiyu Dong5

  • 1Department of Medical Oncology, Hôpital Pitié Salpêtrière, APHP, Sorbonne Université, Paris, France. maloufg@igbmc.fr.

Scientific Reports
|January 22, 2020
PubMed

Insights

Alterations in the Hippo signaling pathway are common in sarcomatoid clear-cell renal cell carcinoma (sRCC). Targeting this pathway may offer new therapeutic strategies for this aggressive cancer.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Sarcomatoid clear-cell renal cell carcinoma (sRCC) presents a poor prognosis.
  • The genomic underpinnings of sarcomatoid dedifferentiation remain largely unknown.

Purpose of the Study:

  • To elucidate the genomic landscape of sRCC.
  • To identify potential therapeutic targets for sRCC.

Main Methods:

  • Targeted panel sequencing was employed on sRCC samples, including microdissected sarcomatoid and epithelial components.
  • Functional assays were conducted to assess the impact of Hippo pathway alterations.

Main Results:

  • The Hippo signaling pathway was frequently altered in sRCC and showed differential enrichment compared to non-sRCC.
  • Mutations in Hippo pathway members correlated with increased nuclear accumulation of YAP/TAZ.
  • In an NF2-mutant sRCC model, YAP1 knockdown and NF2 restoration inhibited tumor growth and invasion.

Conclusions:

  • Hippo pathway alterations are a characteristic feature of sRCC.
  • The Hippo pathway represents a promising novel therapeutic target for sRCC.

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