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Enoxacin penetration into human prostatic tissue.

M G Bergeron1, R Roy, C Lessard

  • 1Infectious Disease Service, Le Centre Hospitalier de l'Université Laval, Quebec, Canada.

Antimicrobial Agents and Chemotherapy
|September 1, 1988
PubMed
Summary
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Enoxacin concentrations in serum and prostate tissue were measured in 14 patients. Results showed higher enoxacin levels in prostate tissue than serum, exceeding minimum inhibitory concentrations for common urinary pathogens.

Area of Science:

  • Pharmacokinetics and Drug Distribution
  • Urology and Infectious Diseases

Background:

  • Bacterial prostatitis is a common condition requiring effective antibiotic therapy.
  • Understanding antibiotic penetration into prostatic tissue is crucial for treatment success.

Purpose of the Study:

  • To determine concurrent enoxacin concentrations in serum and prostatic tissue.
  • To assess the ratio of enoxacin levels in prostatic tissue versus serum.
  • To evaluate if enoxacin concentrations achieve levels effective against common urinary pathogens.

Main Methods:

  • Serum and prostatic tissue samples were collected from 14 patients undergoing prostate surgery.
  • Enoxacin concentrations were measured concurrently in both matrices.
  • Tissue-to-serum concentration ratios were calculated.

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Main Results:

  • The mean ratio of enoxacin concentration in prostatic tissue to serum was 1.4 (±0.2 SEM).
  • Enoxacin levels in both serum and prostatic tissue were generally above the Minimum Inhibitory Concentrations (MICs) for most common urinary pathogens.

Conclusions:

  • Enoxacin demonstrates favorable penetration into prostatic tissue.
  • Achieved concentrations suggest enoxacin may be effective for treating bacterial prostatitis.
  • Further clinical studies are warranted to confirm efficacy.