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Related Experiment Videos

Roxithromycin disposition in tonsils after single and repeated administrations.

G B Galioto1, G Ortisi, E Mevio

  • 1Clinical ORL Università di Pavia, Italy.

Antimicrobial Agents and Chemotherapy
|September 1, 1988
PubMed
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This study measured roxithromycin levels in tonsil tissue and serum after single or multiple oral doses. Roxithromycin was detected in tonsil tissue, showing higher concentrations with multiple dosing, suggesting good tissue penetration for this antibiotic.

Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Infectious Diseases

Background:

  • Tonsillectomy is a common surgical procedure.
  • Understanding antibiotic penetration into tonsil tissue is crucial for effective treatment of tonsillar infections.
  • Roxithromycin is a macrolide antibiotic used to treat bacterial infections.

Purpose of the Study:

  • To investigate the levels of roxithromycin in serum and tonsil tissue.
  • To compare drug concentrations after single versus multiple oral doses.
  • To determine the tissue-to-serum concentration ratio of roxithromycin.

Main Methods:

  • 29 subjects undergoing tonsillectomy were enrolled.
  • Group 1: 13 subjects received a single 300 mg oral dose.
  • Group 2: 16 subjects received multiple doses (300 mg loading dose followed by three 150 mg doses 12 hours apart).

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  • Serum and tonsil tissue samples were collected and analyzed for roxithromycin levels.

    • Main Results:

    • Roxithromycin was detected in tonsil tissue in 11/13 subjects (single dose) and 14/16 subjects (multiple dose).
    • Mean tonsil tissue levels were 0.8 µg/g (single dose) and 1.6 µg/g (multiple dose).
    • Mean tissue/serum ratios were 0.16 (single dose) and 0.23 (multiple dose), indicating increased tissue penetration with multiple dosing.

    Conclusions:

    • Roxithromycin achieves measurable concentrations in human tonsil tissue.
    • Multiple dosing regimens result in higher tonsil tissue levels compared to a single dose.
    • These findings support the potential efficacy of roxithromycin in treating tonsillar infections.