Permanent Pacemaker Implantations after Catheter Ablation in Patients with Atrial Fibrillation Associated with Underlying Sinus Node Dysfunction
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Updated: Dec 30, 2025

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Published on: May 26, 2015
Tae Hyun Hwang1, Hee Tae Yu1, Tae Hoon Kim1
1Department of Cardiology, Yonsei University Health System, Seoul, Korea.
Insights
Approximately 1 in 9 patients with atrial fibrillation and sinus node dysfunction require pacemaker implantation after catheter ablation. Over half of these implantations occur within three months, with higher atrial fibrillation recurrence rates observed in patients needing pacemakers.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Device Technology
Background:
- Atrial fibrillation (AF) and sinus node dysfunction (SND) often coexist.
- Catheter ablation is a common treatment for AF.
- The impact of AF catheter ablation on patients with underlying SND requires further investigation.
Purpose of the Study:
- To assess long-term clinical outcomes after AF catheter ablation in patients with SND.
- To determine the incidence of permanent pacemaker implantation in this patient group.
- To identify factors associated with pacemaker implantation post-ablation.
Main Methods:
- Retrospective analysis of 222 patients with AF and SND undergoing AF catheter ablation (AFCA).
- Evaluation of rhythm outcomes, heart rate variability, and pacemaker implantation rates.
- Follow-up duration averaged 47.5 months.
Main Results:
- 11.3% of patients (25/222) required permanent pacemaker implantation due to symptomatic SND.
- Over half of pacemaker implantations (56.0%) occurred within 3 months post-AFCA.
- Patients requiring pacemakers had significantly higher AF recurrence rates and antiarrhythmic drug use.
Conclusions:
- Permanent pacemaker implantation is a significant long-term outcome after AFCA in patients with SND.
- Early pacemaker implantation is common, necessitating close monitoring within the first three months.
- Higher AF recurrence rates in pacemaker recipients suggest a complex interplay between AF, SND, and ablation outcomes.
Background And Objectives:
The objective of this study was to evaluate the long-term clinical outcomes and the incidence of permanent pacemaker implantation after catheter ablation in patients with of atrial fibrillation (AF) and sinus node dysfunction (SND).
Methods:
Among 3,068 total consecutive patients who underwent AF catheter ablation (AFCA), this study included 222 (9.5%; men 53.2%, 63.7±9.2 years of age, 81.5% paroxysmal AF) with underlying SND and a regular rhythm follow-up. We analyzed the rhythm outcomes, changes in the mean heart rate or heart rate variability, and permanent pacemaker implantation rate.
Results:
During 47.5±28.8 months of follow-up, 25 (11.3%) patients received pacemaker implantations due to symptomatic SND. More than half (56.0%, 14/25) underwent a pacemaker implantation within 3 months of the AFCA, and the annual pacemaker implantation rate was 2.0% afterwards. Both the early (68.0% vs. 31.0%, p<0.001) and clinical AF recurrence (68.0% vs. 32.5%, p=0.001) rates and continuous antiarrhythmic drug use after 3 months (44.0% vs. 24.4%, p=0.036) were significantly higher in patients requiring pacemaker implantations than those that did not. An anterior linear ablation (odds ratio [OR], 9.37 [3.03-28.9]; p<0.001) and the E/Em (OR, 1.15 [1.02-1.28]; p=0.018) were independently associated with permanent pacemaker implantations after AFCA in patients with AF and SND.
Conclusions:
After AFCA in patients with AF and SND, 1 of 9 patients needed a pacemaker implantation and half needed implantations within 3 months. The AF recurrence rate was significantly higher in those who required pacemaker implantations after the AFCA.
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