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Updated: Dec 30, 2025

Author Spotlight: Integrating 2D-HPLC-MS and Molecular Networking in Natural Medicine Analysis
Published on: December 8, 2023
Four new polyynes from Codonopsis pilosula collected in Yunnan province, China
Jin-Song Su1, Fu-Ying Qin2, Ying Liu2
1School of Ethnic medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Abstract:
Choushenpilosulynes D-G (1-4): four new polyynes were isolated from the roots of Codonopsis pilosula (Campanulaceae) cultivated in Yunnan province, China. Their structures were identified by spectroscopic methods. Bioactive evaluation showed that choushenpilosulynes E (2) and F (3) demonstrated potent inhibitory effect on lipid formation induced by 100 μM oleic acid stimulation. In addition, choushenpilosulyne F (3) uncovered inhibitory activity against the expression of human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and squalene monooxygenase (SQLE) gene transcript in HepG2 cells.
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