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Chondronectin in human synovial fluid.

S Carsons1, V J Horn

  • 1Department of Medicine, Long Island Jewish Medical Center, SUNY, Stony Brook.

Annals of the Rheumatic Diseases
|October 1, 1988
PubMed
Summary
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Chondronectin, a cartilage protein, was found in synovial fluid from patients with rheumatoid and osteoarthritis. Its presence suggests a potential link to joint disease and plasma origin.

Area of Science:

  • Biochemistry
  • Immunology
  • Rheumatology

Background:

  • Chondronectin is a key cartilage matrix protein.
  • It mediates chondrocyte attachment to type II collagen.

Purpose of the Study:

  • To detect, measure, and characterize chondronectin in human synovial fluid.
  • To investigate the origin and potential role of chondronectin in joint diseases.

Main Methods:

  • Competitive enzyme-linked immunosorbent assay (ELISA).
  • Western blot assay.
  • Monoclonal antibody to chondronectin.

Main Results:

  • Chondronectin was detected in all examined synovial fluids from rheumatoid arthritis and osteoarthritis patients.

Related Experiment Videos

  • Synovial fluid chondronectin concentrations were lower than plasma levels.
  • Concentrations correlated with synovial fluid albumin and fibrinogen, suggesting plasma origin.

    • Conclusions:

    • Synovial fluid chondronectin is likely partially derived from plasma.
    • Chondronectin may serve as a marker for cartilage destruction.
    • It could potentially mediate pannus formation in joint diseases.